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Universidad CEU-San Pablo.
Urb. Montepríncipe. 28925 Alcorcón, Madrid (España).
Phone. (+34) 91 372 47 69.
Metabolomics is a new approach to study a biological situation without any preliminary hypothesis. Ideally, it is the study of the unique chemical fingerprints that specific cellular processes leave behind, specifically of their small molecule metabolite profiles. In practice, we work by differential analysis of sample profiles (metabolic fingerprinting). In summary, analytical techniques are employed to develop as many signals as possible from a sample (urine, plasma, cell cultures, tissue extracts…) as intact as possible. Profiles of the samples from the situation under the study and the corresponding controls are compared by applying multivariate data analysis and those signals significantly different in both groups are identified as candidate markers.
These signals are later submitted to structural elucidation to have tentative markers that should be validated. This approach has experience and explosion in interest from a variety of disciplines ranging from basics biology to all kind of clinical applications and even in food sciences. Researchers are now utilizing the power of metabolomics to examine underlying biology and mechanism of disease, for drug development¸ toxicity studies, for the identification of disease diagnostic and prognostic markers and even for assessing the effects of environmental changes.
CEMBIO has capacity of tackling aspects such as experimental designs, analytical methods, appropriate statistical methods for metabolomics and biochemical interpretation.
Coral Barbas is currently Full Professor of Analytical Chemistry at the Chemistry and Biochemistry Department of the Faculty of Pharmacy at Universidad CEU San Pablo, Madrid (Spain) and Director of the “Centre for Metabolomics and Bioanalysis” (CEMBIO) at this Faculty. She is also Director of CEU International School of Doctorate (CEINDO); Visiting Professor at Imperial College London, Department of Surgery and Cancer and at Bialystok Medical University. As previous appointments, she was Vice-Chancellor for Research at Universidad CEU San Pablo and Marie Curie Fellow at Kings College London. She is the author of more than 200 publications and book chapters, with current research interests in all the steps in metabolomics workflow: experimental design, sample pretreatment, analytical methods for targeted and untargeted metabolomics focused on multiplatform analysis with GC-MS, LC-MS and CE-MS, method validation, data treatment, compound identification and interpretation.
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